**you end up getting less range** -> you need to get the cutoff right. Watt hours are watt hours. Doesn’t matter if Li-Ion or LiPo. As far as i know you did set the cutoff to 3.3V for each cell which is too high and a result of my first post of this thread.
**stressing your cells more** -> You don’t stress the cells more because that is what they are build for.
**will only get 400 charge cycles** -> that is roughly 10000km for a 10S4P

The only difference will be your max power output compared to a Li-Ion and the max speed because of the motors kv which depend on the voltage…

So at 80 amps under load for a 10S4P this would be 20A for each cell.

**Fully charged Li-Ion** can handle 3,7V at 20A load:
3,7V (cell under load) * 10S * 80A = 2960 Watts

**Fully charged Li-Po** can handle 3,9V at 20A load:
3,9V (cell under load) * 10S * 80A = 3120 Watts (160 watts more)

**Close to empty Li-Ion**, so that we reach the voltage cutoff for the VESC at 2,8V:
2,8V (cell under load) * 10S * 80A = 2240 Watts

**Close to empty Li-Po**, so that we reach the voltage cutoff for the VESC at 3,3V:
3,3V (cell under load) * 10S * 80A = 2640 Watts (400 watts more)

So the the LiPo Batterys can deliver more power at different discharge levels. But that’s it. So if you only want to blast up the steepest hills then it makes sense. But i think many people don’t even get close to those watts.
And if the cutoff end is set wrong for Li-Ion cells (like 3.3V) then you reduce the battery to half of what it would be capable. So 2.8V would be right.